I-5-amino-1-methylquinolinium iodide ye-CAS No.:42464-96-0 98.0% ubumsulwa min. | umenzi wezithako engeza
Amapharamitha womkhiqizo
| Igama lomkhiqizo | 5-amino-1-methylquinolinium iodide |
| Elinye igama | NNMTi5-Amino-1-mq iodide 5-amino-1-methylquinolinium iodide 5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine;iodide 5-Amino-1-methyl-1-quinolinium Iodide |
| Inombolo ye-CAS. | 42464-96-0 |
| Ifomula yamangqamuzana | I-C10H11IN2 |
| Isisindo samangqamuzana | 286.11 |
| Ubumsulwa | 98% |
| Ukubukeka | Okuqinile okunsundu kuya kokubomvu okunsundu |
| Ukupakisha | 1kg/isikhwama, 25kg/umgqomo |
| Isicelo | I-Dietary Supplement Raw Material |
Isingeniso somkhiqizo
I-NNMTi iyi-enzyme egcizelelwe ngokweqile ngesikhathi sokuguga kwemisipha yamathambo futhi ihlotshaniswa nokulungiswa komonakalo wendlela ye-NAD+, umsebenzi ongasebenzi kahle we-sirtuin1, kanye nokukhula kwe-muscle stem cell senescence. I-NNMTi ikhuthaza ukuhlukaniswa kwe-myoblast ku-vitro futhi ithuthukise ukuhlanganiswa nokuvuselelwa kwamaseli e-muscle stem kumagundane amadala. I-NNMTi iphinde ibe isivimbeli esinamandla se-nicotinamide N-methyltransferase (NNMT) (IC50=1.2 μM), ngokukhetha okubophezela ezinsalela zesayithi ezibophezelayo ze-NNMT. I-NNMTi ikhuthaza ukuhlukaniswa kwe-myoblast ku-vitro futhi ithuthukise ukuhlanganiswa nokuvuselelwa kwamaseli e-muscle stem kumagundane amadala. Phakathi kwazo, i-cytosolic enzyme i-nicotinamide N-methyltransferase (NNMT) isanda kutholwa ukulawula amazinga e-nicotinamide precursors adingekayo ku-NAD+ biosynthesis, ngakho-ke idlala indima ebalulekile ekulawuleni indlela yokusindisa ye-NAD+ kanye ne-metabolism yamaselula.
Isici
(1) Ukuhlanzeka okuphezulu: I-NNMTi ingathola imikhiqizo ehlanzekile ngezinqubo zokukhiqiza ezicolisisiwe. Ukuhlanzeka okuphezulu kusho i-bioavailability engcono.
(2) Ukuqondisa: I-NNMti iqondise ngokuqondile i-enzyme ye-NNMT futhi ingavimbela ngempumelelo umsebenzi wayo, ngaleyo ndlela ithinte indlela ye-metabolic ye-nicotinamide.
(3) Ukuzinza: I-NNMTi inokuzinza okuhle futhi ingagcina umsebenzi wayo nomthelela ngaphansi kwezimo ezihlukene nezimo zokulondoloza.
(4) Amathemba okuthuthuka: Ngenxa yezici ezihlukahlukene ze-NNMT, ukuthuthukiswa kwayo kuthole ukunakwa okusabalele futhi kunocwaningo olubanzi nethuba lokusetshenziswa.
Izinhlelo zokusebenza
I-NNMTi iyi-nicotinamide N-methyltransferase (NNMT) inhibitor ekhuthaza ukuhlukaniswa kwe-myoblast. I-NNMTi ingasetshenziswa futhi njengesithasiselo ukusiza ukunciphisa isisindo namafutha kanye nokwenza ngcono amafutha esibindi.
