5-Amino-1-methylquinolinium chloride Inombolo ye-CAS:42464-96-0 ubumsulwa obungu-98.0% ubuncane | umenzi wezithako ezengeziwe
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-5-Amino-1-methylquinolinium chloride (5-amino-1MQ) |
| Elinye igama | 5-amino-1MQI-chloride engu-5-Amino-1-mq I-5-Amino-1-methylquinolinium chloride 5-Amino-1-methylquinolin-1-ium chloride 5-AMINO-1-METHYLQUINOLIN-1-IUM CHLOEIDE I-5-Amino-1-methyl-1-quinolinium chloride |
| Inombolo ye-CAS | 42464-96-0 |
| Ifomula yama-molecule | C₁₀H₁₁ClN₂ |
| Isisindo sama-molecule | 194.6 |
| Ubumsulwa | 98% |
| Ukubukeka | Okuqinile okunsundu kuya kokubomvu |
| Ukupakisha | 1kg/isikhwama, 25kg/ibhareli |
| Isicelo | Isengezo Sokudla Izinto Ezingavuthiwe |
Isingeniso somkhiqizo
I-5-Amino-1-methylquinolinium chloride iyi-enzyme evezwa kakhulu ngesikhathi sokuguga kwemisipha yamathambo futhi ihlotshaniswa nokulungiswa komonakalo wendlela ye-NAD+, umsebenzi we-sirtuin1 ongasebenzi kahle, kanye nokukhula kwe-muscle stem cell. I-5-Amino-1-methylquinolinium chloride ikhuthaza ukuhlukaniswa kwe-myoblast in vitro futhi ithuthukisa ukuhlanganiswa nokuvuselelwa kwamaseli e-muscle stem kumagundane asebekhulile. I-5-Amino-1-methylquinolinium chloride nayo iyisithiyo esinamandla se-nicotinamide N-methyltransferase (NNMT), ebopha ngokukhetha kuma-residue e-NNMT substrate binding site. I-5-Amino-1-methylquinolinium chloride ikhuthaza ukuhlukaniswa kwe-myoblast in vitro futhi ithuthukisa ukuhlanganiswa nokuvuselelwa kwamaseli e-muscle stem kumagundane asebekhulile. Phakathi kwazo, i-cytosolic enzyme nicotinamide N-methyltransferase (NNMT) isanda kutholwa ukulawula amazinga e-nicotinamide precursors adingekayo ku-NAD+ biosynthesis, ngakho-ke idlala indima ebalulekile ekulawuleni indlela yokusindisa i-NAD+ kanye ne-metabolism yamaseli.
I-5-Amino-1-Methylquinolinium Chloride isebenza ngaphakathi kwe-microbiome yakho ukunciphisa izicubu zamafutha futhi ikusize unciphise isisindo. Lapho amaseli amafutha engeziwe eqoqana, umzimba wakho ukhiqiza ngokweqile i-enzyme eyaziwa ngokuthi i-NNMT (i-nicotinamide N-methyltransferase). Uma i-NNMT iningi, umzimba wakho ukhulisa ukuvuvukala futhi ugcina amafutha. I-5-Amino-1-Methylquinolinium Chloride ivimbela i-NNMT, okuvumela umzimba wakho ukuthi wehlise isisindo esiningi.
Isici
(1) Ubumsulwa obuphezulu: I-5-Amino-1-methylquinolinium chloride ingathola imikhiqizo yobumsulwa obuphezulu ngezinqubo zokukhiqiza ezicwengisisiwe. Ubumsulwa obuphezulu busho ukutholakala okungcono kwe-bioavailability.
(2) Ukuqondisa: I-5-Amino-1-methylquinolinium chloride ihlose ngqo i-enzyme ye-NNMT futhi ingavimbela ngempumelelo umsebenzi wayo, ngaleyo ndlela ithinte indlela ye-metabolic ye-nicotinamide.
(3) Ukuzinza: I-5-Amino-1-methylquinolinium chloride inokuqina okuhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.
(4) Amathemba okuthuthuka: Ngenxa yezici ezahlukahlukene ze-5-Amino-1-methylquinolinium chloride, intuthuko yayo ithole ukunakwa kabanzi futhi inocwaningo olubanzi kanye namathemba okusetshenziswa.
Izicelo
I-5-Amino-1-methylquinolinium chloride iyisithibi se-nicotinamide N-methyltransferase (NNMT) esikhuthaza ukuhlukaniswa kwe-myoblast. I-5-Amino-1-methylquinolinium chloride ingasetshenziswa futhi njengesengezo ukusiza ukunciphisa isisindo namafutha nokuthuthukisa amafutha esibindi.
