I-Agomelatine powder umkhiqizi we-CAS No.: 138112-76-2 99% ubumsulwa min. okwengeza izithako
Ividiyo Yomkhiqizo
Amapharamitha womkhiqizo
| Igama lomkhiqizo | I-Agomelatine |
| Elinye igama | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| Inombolo ye-CAS. | 138112-76-2 |
| Ifomula yamangqamuzana | I-C15H17NO2 |
| Isisindo samangqamuzana | 243.3082 |
| Ubumsulwa | 99.0% |
| Ukubukeka | Impushana emhlophe |
| Ukupakisha | 1kg/isikhwama 25kg/isigubhu |
| Isicelo | Impahla yomkhiqizo wezempilo |
Isingeniso somkhiqizo
I-Agomelatine yethulwa okokuqala e-Europe ngo-2009 futhi manje isigunyazwe ukusetshenziswa emazweni angaphezu kuka-70. Ngokungafani nama-antidepressants endabuko, i-agomelatine isebenza ngokukhomba i-melatonin nama-serotonin receptors ebuchosheni. Ngokusebenza njenge-agonist kuma-melatonin receptors, i-agomelatine isiza ekwenzeni amaphethini okulala aphazamisekile avame ukuhlotshaniswa nokudangala. Lo mshini awusizi nje kuphela ukuthuthukisa ikhwalithi yokulala kodwa futhi usiza ukubuyisela isigqi semvelo se-circadian. Ngaphezu kwalokho, i-agomelatine yenza njengomphikisi kuma-serotonin receptors athile (ama-5-HT2C receptors). Lesi senzo esikabili esiyingqayizivele sithuthukisa ngokungaqondile ukutholakala kwe-serotonin ebuchosheni, i-neurotransmitter enesibopho sokulawula isimo sengqondo. Ngokulawula amazinga e-serotonin, i-agomelatine ingasebenza njenge-antidepressant ephumelelayo, ekhulula izimpawu ezifana nokudabuka, ukulahlekelwa isithakazelo, imizwa yecala noma yokungabi nto yalutho. Ukwengeza, i-agomelatine ingase inikeze ezinye izinzuzo. Ucwaningo luphakamisa ukuthi lungasiza ukuthuthukisa ukusebenza kwengqondo Ucwaningo lubonisa amandla alo okuthuthukisa inkumbulo, ukunaka, kanye nomsebenzi wokuphatha, okwenza kube indawo ethokozisayo yocwaningo lwangomuso.
Isici
(1) Ukuhlanzeka okuphezulu: I-Agomelatine ingathola imikhiqizo ehlanzekile ngezinqubo zokukhiqiza zokucwenga. Ukuhlanzeka okuphezulu kusho i-bioavailability engcono kanye nokusabela okungekuhle okumbalwa.
(2) Ukuphepha: Ukuphepha okuphezulu, ukusabela okumbalwa okungekuhle.
(3) Ukuzinza: I-Agomelatine inokuzinza okuhle futhi ingagcina umsebenzi wayo nomthelela ngaphansi kwezimo ezihlukene nezimo zokugcina.
Izinhlelo zokusebenza
I-Agomelatine iyi-antidepressant kanye nomphikisi we-melatonin. Yehlisa izimpawu zokucindezeleka ngokulawula i-melatonin MT1 receptors (yehlisa amasignali e-alamu ye-cortical) kanye nama-MT2 receptors (isigqi sokulala se-circadian) namazinga e-serotonin. Ithathwa ebusuku, ilingisa isigqi semvelo sokukhishwa kwe-melatonin futhi ingathuthukisa kakhulu ikhwalithi yokulala. Indlela yokusebenza kwayo inqamula ohlelweni lwendabuko lokudlulisela i-monoamine. Ivula ama-melatonin receptors MT1 kanye ne-MT2 futhi iphikisane nama-5-HT2C receptors. Ithuthukisa ikhwalithi yokulala, ibuyisela isigqi sebhayoloji, futhi inomphumela we-antidepressant; phakathi kwazo, ngokuphikisana nama-receptors e-5-HT2C kulwelwesi lwe-postsynaptic, kungakhuphula ukukhululwa kwe-DA ne-NE ku-prefrontal cortex, kube nomphumela wokudambisa. Lapho i-MT agonism kanye ne-5-HT2C yokuphikisa kwe-receptor antagonism kuhlangene, umphumela oyingqayizivele we-synergistic ungakhiqizwa, ukhuthaza ukukhululwa kwe-DA ne-NE eningi endaweni yobuchopho be-PFC, ngokuqhubekayo kuqinisa umphumela we-antidepressant. Ngaphezu kwalokho, i-agomelatine ingakhuthaza ukukhululwa kwe-neurotrophic factor etholakala ebuchosheni ku-PFC futhi ivimbele ukukhululwa okubangelwa ukucindezeleka kwe-glutamate endaweni yobuchopho be-amygdala.
