Umkhiqizi wempuphu ye-Amino Tadalafil Inombolo ye-CAS: 385769-84-6 Ubumsulwa obungu-98% okungenani bezithako ezengeziwe
Ividiyo Yomkhiqizo
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-Amino Tadalafil |
| Elinye igama | (6R,12aR)-2-Amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;AminoTadalafil(6R,12Ar)-2-Amino-6-(1,3-Benzodioxol-5-Yl)-2,3,6,7,12,12A-Hexahydropyrazino[1',2':1,6]Pyrido[3,4-B]Indole-1,4-Dion e;(6R,12aR)-2-Amino-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-1,4-dione;(6R,12aR)-2-amino-6-(benzo[d][1,3]dioxol-5-yl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
| Inombolo ye-CAS | 385769-84-6 |
| Ifomula yama-molecule | C21H18N4O4 |
| Isisindo sama-molecule | 390.39 |
| Ubumsulwa | 98.0% |
| Ukubukeka | Impuphu emhlophe kuya kwemhlophe kakhulu |
| Isicelo | Isengezo Sokudla Izinto Ezingavuthiwe |
Isingeniso somkhiqizo
I-Amino Tadalafil iyinhlanganisela entsha, etholakala ku-tadalafil, ethandwa kakhulu emkhakheni wokungasebenzi kahle kwe-erectile (ED). Ihlanganisa i-amino acid ne-tadalafil, i-PDE5 inhibitor evunyelwe yi-FDA esetshenziswa kakhulu ukwelapha i-ED. Isebenza ngokwandisa ukugeleza kwegazi kuya epenis, okuvumela amadoda ukuthi afinyelele futhi alondoloze ukwakheka. Ama-amino acid, ngakolunye uhlangothi, adlala indima ebalulekile emisebenzini eyahlukene yomzimba, okuhlanganisa nokukhiqizwa kwamaprotheni, okuyizinto zokwakha izicubu nezitho zomzimba. Ukuhlanganiswa kwalezi zithako ezimbili kuklanyelwe ukuthuthukisa ukusebenza kwe-Tadalafil ekwelapheni i-ED. Futhi i-amino Tadalafil iyinguqulo ethuthukisiwe enamandla angavamile, okuthuthukisa ukusebenza kanye nokuguquguquka kwesandulela sayo. Isakhiwo sayo samakhemikhali sisafana ne-Tadalafil, kodwa ngokwethulwa kwamaqembu ama-amino, ithola izimfanelo ezihlukile ezenza ivelele ezweni lemithi. Njenge-tadalafil, i-Amino Tadalafil isebenza ngokuvimbela i-phosphodiesterase 5 (PDE5), i-enzyme ebhekene nokuphula i-cyclic guanosine monophosphate (cGMP) emzimbeni. I-cGMP iyinhlanganisela yemvelo ekhuthaza ukukhululeka kwemithambo yegazi, ngaleyo ndlela yandise ukugeleza kwegazi. Ngokuvimbela i-PDE5, i-amino Tadalafil iqinisekisa ukuqongelela kwe-cGMP, ngaleyo ndlela ithuthukise ukugeleza kwegazi futhi ithuthukise ukujikeleza kwegazi. Ngaphezu kwalokho, abacwaningi bahlole amandla ayo okusiza ekwelapheni i-benign prostatic hyperplasia (BPH) ngokukhuthaza ukugeleza kwegazi ku-prostate.
Isici
(1) Ukuhlanzeka okuphezulu: I-Amino Tadalafil ingathola imikhiqizo ehlanzeka kakhulu ngezinqubo zokukhiqiza zokucwenga. Ukuhlanzeka okuphezulu kusho ukutholakala okungcono kwe-bioavailability kanye nokusabela okuncane okubi.
(2) Ukuphepha: Ukuphepha okuphezulu, ukusabela okungekuhle okumbalwa.
(3) Ukuzinza: I-Amino Tadalafil inokuzinza okuhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.
Izicelo
I-Amino Tadalafil iyisivimbeli se-PDE5 esinemiphumela efanayo yezokwelapha njenge-tadalafil. Ngokuhlanganisa ama-amino acid ne-tadalafil, kucatshangwa ukuthi i-amino Tadalafil iphumelela kakhulu ekwelapheni ukungasebenzi kahle kwe-erectile kune-tadalafil yodwa. Ama-amino acid angasiza ekuthuthukiseni ukujikeleza kwegazi futhi asekele ukusebenza kahle kwemithi. Ngaphezu kwalokho, ingathuthukisa izimpawu zokungasebenzi kahle kwe-erectile (ED) ngokuvimbela umsebenzi we-enzyme ye-PDE5 ukukhuthaza ukugeleza kwegazi ezithweni zokuzala zesilisa. Uma kuqhathaniswa ne-tadalafil, i-amino Tadalafil iguqulwa kancane emzimbeni futhi ingaveza imiphumela ehlala isikhathi eside. Lokhu kunikeza i-amino Tadalafil amandla amakhulu ekwelapheni i-ED.
