I-Agomelatine powder umkhiqizi we-CAS No.: 138112-76-2 99% ubumsulwa min.okwengeza izithako
Amapharamitha womkhiqizo
| Igama lomkhiqizo | I-Agomelatine |
| Elinye igama | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| Inombolo ye-CAS. | 138112-76-2 |
| Ifomula yamangqamuzana | I-C15H17NO2 |
| Isisindo samangqamuzana | 243.3082 |
| Ubumsulwa | 99.0% |
| Ukubukeka | Impushana emhlophe |
| Ukupakisha | 1kg/isikhwama 25kg/isigubhu |
| Isicelo | Impahla yomkhiqizo wezempilo |
Isingeniso somkhiqizo
I-Agomelatine uhlobo olusha lwe-antidepressant.Indlela yayo yokusebenza inqamula kuhlelo lwendabuko lokudlulisela i-monoamine.Ivula ama-melatonin receptors, i-MT1 ne-MT2, futhi iphikisane nama-receptors angu-5-HT2C.Ingathuthukisa ikhwalithi yokulala futhi ibuyisele isigqi sebhayoloji ngenkathi inomphumela we-antidepressant;phakathi kwabo, ngokuphikisana ne-5-HT2C receptor ye-postsynaptic membrane, ingakhuphula ukukhululwa kwe-DA ne-NE ku-prefrontal cortex futhi idlale indima yokucindezeleka.Lapho i-MT agonism kanye ne-5-HT2C yokuphikisa kwama-receptor kukhona ngesikhathi esifanayo, umphumela oyingqayizivele we-synergistic ungakhiqizwa ukuze kuthuthukiswe ukukhululwa kwe-DA ne-NE eningi endaweni yobuchopho be-PFC, ngokuqhubekayo ukuqinisa umphumela we-antidepressant.Ngaphezu kwalokho, i-agomelatine ingaphinde ikhuthaze ukukhululwa kwe-neurotrophic factor etholakala ebuchosheni ku-PFC futhi ivimbele ukukhululwa okubangelwa ukucindezeleka kwe-glutamate esifundeni sobuchopho be-amygdala.
Isici
(1) Ukulawulwa okubili: Akukwazi nje ukulawula ukukhululwa kwe-melatonin, kodwa futhi ukulawula ukukhululwa kwe-5-hydroxytryptamine ne-norepinephrine, ngaleyo ndlela idlala indima ekulawuleni isimo sengqondo, ukulala, ubuhlungu nokunye.
(2) Ukuthuthukiswa kokulala: I-Agomelatine ingase ithuthukise ukuqwasha ngaphandle kokubangela ukozela noma i-coma.
(3) Thuthukisa umsebenzi wokuqonda: I-Agomelatine ingathuthukisa ukusebenza kwengqondo ngokuthuthukisa i-neuroplasticity ku-hippocampus.
(4) Ukuphepha okuphezulu: Uma kuqhathaniswa namanye ama-antidepressants, umuthi unemiphumela engemihle kancane uma ukwelapha ukucindezeleka, futhi ngeke kuthinte ukusebenza kocansi nesisindo somzimba.
Izinhlelo zokusebenza
I-Agomelatine ingeye-antidepressant nayo engumphikisi we-melatonin.Yehlisa izimpawu zokucindezeleka ngokushintsha amazinga e-melatonin MT1 receptors (ukunciphisa amasignali e-alamu ye-cortical) nama-MT2 receptors (esigqi sokulala esijikelezayo) kanye ne-serotonin.Kuthathwa ebusuku ukulingisa isigqi semvelo sokukhishwa kwe-melatonin, kungathuthukisa kakhulu ikhwalithi yokulala.
