YDL223C (HBT1) umenzi we-powder CAS No.: 489408-02-8 99% ubumsulwa min. okwengeza izithako

I-HBT1 ibophezela kusizinda esibopha i-ligand se-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) ngendlela encike ku-glutamate. Lokhu kusho ukuthi i-HBT1 i-molecule engabophezela kuphela endaweni ethile kuphrotheni ye-AMPA-R uma kukhona i-glutamate, futhi lokhu kubophezela kusiza ukulawula umsebenzi wephrotheni. Ama-receptors e-AMPA avezwa kulo lonke uhlelo lwezinzwa olumaphakathi futhi adlala indima ebalulekile ekuxhumaneni kwe-neuronal, ukucubungula izinzwa, ukufunda, inkumbulo, kanye ne-synaptic plasticity. Ama-receptors e-AMPA angabavikeli abakhulu ekudluliselweni kwemithambo-luvo okujabulisayo, alamula ngokushesha, ngokushesha aqede ukungezwani komzimba kuma-synapses amaningi, futhi abandakanyeka ekuphenduleni kwangaphambi kwesikhathi kwe-glutamate ezifundeni ze-synaptic. Ama-receptors e-AMPA avame ukuvezwa ngokubambisana nama-NMDA receptors kuma-synapses, futhi ndawonye akhuthaza izinqubo ze-synaptic plasticity ezibandakanyeka ekufundeni, inkumbulo, i-excitotoxicity, kanye ne-neuroprotection. I-brain-derived neurotrophic factor (BDNF) iyisici se-neurotrophic esidlala indima ebalulekile ekugcinweni nasekukhuliseni ama-neurons futhi sinemiphumela enamandla futhi eminingi ekwandeni, ukuhlukaniswa, ukusinda nokufa kwamaseli e-neuronal kanye ne-non-neuronal. , i-modulator ye-neurotransmitter efaka isandla ku-neuronal plasticity ekufundeni nasenkumbulo. Ngakho-ke, kubalulekile empilweni nasenhlalakahleni yesimiso sezinzwa.