Umkhiqizi wempuphu ye-Riboside engu-1,4-DihydronicotinaMide Inombolo ye-CAS:19132-12-8 Ubumsulwa obungu-98% obuncane bezithako ezengeziwe
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-Riboside ye-DihydronicotinaMide engu-1,4- |
| Elinye igama | I-1,4-DIHYDRONICOTINAMIDE RIBOSIDE1-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,4-dihydropyridine-3-carboxamideI-SCHEMBL188493711-[(3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-4H-PYRIDINE-3-CARBOXAMIDE |
| Inombolo ye-CAS | 19132-12-8 |
| Ifomula yama-molecule | C11H16N2O5 |
| Isisindo sama-molecule | 256.26 |
| Ubumsulwa | 98% |
| Ukubukeka | Impuphu emhlophe |
| Ukupakisha | 1kg/isikhwama; 25kg/isigubhu |
| Isicelo | Izinto zokusetshenziswa zesengezo sokudla |
Isingeniso somkhiqizo
I-1,4-dihydronicotinamide riboside, eyaziwa nangokuthi i-NRH.Uhlobo oluncishisiwe lwe-NRH luyisandulela se-NAD+ esinamandla esisiza ukugcwalisa amazinga aso esitokisini.
Okokuqala nokubaluleke kakhulu, kubalulekile ukuqonda indima ye-NAD+ emzimbeni. I-NAD+ iyi-coenzyme ehilelekile ezinqubweni eziningi zamaseli, okuhlanganisa ukugaya amandla, ukulungiswa kwe-DNA, kanye nokubonakaliswa kwezakhi zofuzo. Njengoba siguga, amazinga ethu e-NAD+ ayancipha, okuye kwahileleka enkambisweni yokuguga kanye nezifo ezihlobene nokuguga. Lokhu kuholele entshisakalweni ekhulayo yokuhlonza ama-molecule angakhuphula amazinga e-NAD+ emzimbeni, kanti i-1,4-dihydronicotinamide riboside ingenye yama-molecule anjalo.
I-1,4-dihydronicotinamide riboside iyisandulela se-NAD+ esinamandla, futhi ucwaningo lukhombisile ukuthi ingakhuphula ngempumelelo amazinga e-NAD+ kumaseli. Lokhu kuholele ekuqageleni ukuthi ukwengezwa kwe-1,4-dihydronicotinamide riboside kungaba namandla okwelapha ezimweni eziningi zempilo, kufaka phakathi ukuphazamiseka kwe-metabolic, izifo ze-neurodegenerative, kanye nokwehla okuhlobene nokuguga.
Eqinisweni, kunobufakazi obusikisela ukuthi i-1,4-dihydronicotinamide riboside ingase isebenze kangcono kune-molecule yayo engumzali, i-nicotinamide riboside, ekwandiseni amazinga e-NAD+. Lokhu kungenxa yokuthi i-1,4-dihydronicotinamide riboside iyisinciphisi esinamandla kakhulu, okusho ukuthi ingcono ekunikeleni ama-electron endleleni yokwenziwa kwe-NAD+. Ngenxa yalokho, inamandla okukhuthaza ukukhiqizwa kwe-NAD+ yeselula ngempumelelo.
Ngaphezu kwendima yayo ku-biosynthesis ye-NAD+, i-riboside ye-1,4-dihydronicotinamide nayo inezakhiwo ze-antioxidant. Ukucindezeleka kwe-oxidative, okubangelwa ukungalingani phakathi kwama-free radicals nama-antioxidants emzimbeni, kuhilelekile ezifweni eziningi, kufaka phakathi umdlavuza, isifo senhliziyo, kanye nezinkinga ze-neurodegenerative. Ngokususa ama-free radicals kanye nokunciphisa umonakalo we-oxidative, i-riboside ye-1,4-dihydronicotinamide inganikeza izinzuzo ezengeziwe zezempilo ngaphezu kwendima yayo njengomanduleli we-NAD+.
Isici
(1) Ubumsulwa obuphezulu: I-1,4-dihydronicotinamide riboside ingathola imikhiqizo yobumsulwa obuphezulu ngezinqubo zokukhiqiza ezicwengisisiwe. Ubumsulwa obuphezulu busho ukutholakala okungcono kwe-bioavailability kanye nokusabela okungekuhle okumbalwa.
(2) Ukuphepha: I-1,4-dihydronicotinamide riboside iwumkhiqizo wemvelo oye wafakazelwa ukuthi uphephile emzimbeni womuntu.
(3) Ukuzinza: I-riboside ye-1,4-dihydronicotinamide inokuqina okuhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.
Izicelo
I-1,4-Dihydronicotinamide uhlobo oluncishisiwe lwe-nicotinamide riboside. Ingaba khona kokubili ezinhlotsheni ezincishisiwe nezincishisiwe futhi iyisandulela se-NAD esanda kutholakala (i-nicotinamide adenine dinucleotide), etholakala njengesengezo, kanti i-NRH iyisandulela se-NAD+ esinamandla futhi esisheshayo kune-NR.
