Umkhiqizi wempuphu ye-Nefiracetam Inombolo ye-CAS: 77191-36-7 Ubumsulwa obungu-99% bezithako ezengeziwe
Ividiyo Yomkhiqizo
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-Nefiracetam |
| Elinye igama | n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide;NEFIRACETAM; i-2-oxo-1-pyrrolidinylaceticacid, i-2,6-dimethylanilide; dm9384; n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide;DM-9384,(2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide); I-DMMPA |
| Inombolo ye-CAS | 77191-36-7 |
| Ifomula yama-molecule | C14H18N2O2 |
| Isisindo sama-molecule | 246.3 |
| Ubumsulwa | 99.0% |
| Ukubukeka | Impuphu emhlophe |
| Ukupakisha | 25 kg/umgqomo |
| Isicelo | i-nootropic |
Isingeniso somkhiqizo
I-Nefiracetam ingeyomndeni we-piracetam, uhlobo lwemithi eyaziwa ngezakhiwo zayo zokuthuthukisa ingqondo. I-Nefiracetam yaqala ukwenziwa ekuqaleni kwawo-1980 futhi yasheshe yadonsela ukunaka ngenxa yendlela yayo yokusebenza eyingqayizivele kanye nezicelo zokwelapha ezingaba khona. Le nhlanganisela ye-racemic kucatshangwa ukuthi ithinta ama-neurotransmitter nama-receptor ebuchosheni, ekugcineni ikhuthaza amakhono okuqonda athuthukisiwe. I-Nefiracetam ithinta kakhulu amazinga obuchopho e-acetylcholine, i-neurotransmitter ebalulekile ebhekene nenkumbulo, ukufunda, kanye nomsebenzi wokuqonda. Ngokuguqula ama-receptor e-acetylcholine, i-nefiracetam ikhuthaza ukuxhumana okwandisiwe phakathi kwama-neurons, ngaleyo ndlela ithuthukise i-synaptic plasticity futhi ithuthukise ukugcinwa kwememori. Ngaphezu kwalokho, i-nefiracetam ixhumana nama-receptor e-gamma-aminobutyric acid (GABA) ukusiza ukulinganisela isimo se-neurotransmitter. Ngokuthinta kahle ama-neurotransmitter avuselelayo navimbelayo, i-nefiracetam isiza ukugcina ukusebenza kobuchopho okuhle kakhulu, ngaleyo ndlela ithuthukise ukugxila, ukunaka, kanye nokusebenza kokuqonda okuphelele.
Isici
(1) Ukuhlanzeka okuphezulu: I-Nefiracetam ingathola imikhiqizo ehlanzeka kakhulu ngezinqubo zokukhiqiza zokucwenga. Ukuhlanzeka okuphezulu kusho ukutholakala okungcono kwe-bioavailability kanye nokusabela okuncane okubi.
(2) Ukuphepha: Ukuphepha okuphezulu, ukusabela okungekuhle okumbalwa.
(3) Ukuzinza: I-Nefiracetam izinzile kahle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.
Izicelo
I-Nefiracetam iyi-derivative ye-piracetam e-hydrophobic, ngokuvamile ebhekwa njengento ebangela ukutholakala kweziteshi ze-calcium emzimbeni kanye nokudluliselwa okungaqondile kwezinto ezibonisa ukuvusa njenge-agonist engaphelele yeziteshi ze-calcium ion. Indawo yokubopha i-Glycine ye-NDMA receptor. Ngomphumela wayo ku-cortex yobuchopho, i-nefiracetam ingathuthukisa amakhono okuqonda futhi ivimbele ukukhubazeka kokufunda kanye nenkumbulo. Ayinazo izakhiwo ze-muscarinic receptor agonist noma i-antagonist, futhi ayivimbeli umsebenzi we-acetylcholinease. Ngakho-ke, imiphumela yayo yokulwa ne-amnestic kanye nokuthuthukisa inkumbulo itholakala ngokuthuthukisa ukukhishwa kwe-acetylcholine ku-cortex yobuchopho.
