I-RU58841 umkhiqizi we-powder CAS No.: 154992-24-2 99.0% ubumsulwa min. okwengeza izithako
Amapharamitha womkhiqizo
| Igama lomkhiqizo | 4--[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile |
| Elinye igama | RU58841 |
| Inombolo ye-CAS. | 154992-24-2 |
| Ifomula yamangqamuzana | I-C17H18F3N3O3 |
| Isisindo samangqamuzana | 369.34 |
| Ubumsulwa | 99.0% |
| Ukubukeka | impushana emhlophe |
| Ukupakisha | 1kg/isikhwama |
| Isicelo | Khulisa izinwele |
Isingeniso somkhiqizo
I-RU58841 (eyaziwa nangokuthi i-RU-58841) iyinhlanganisela, i-RU58841 incintisana ne-dihydrotestosterone ukugcina amazinga e-DHT ngaphakathi kwebanga elijwayelekile, ngaleyo ndlela ilawula umjikelezo wokukhula kwezinwele. Ivuselela ukuguqulwa kwezinwele ezintsha zezinwele zibe yizicucu zezinwele ze-anagen ngokungena esigabeni se-anagen. Ukuvumela ama-follicles alimele isikhathi sokushintshela esigabeni sokukhula esivamile kusiza amaseli ukuthi alulame. Ibuye ikhulise ukugeleza kwegazi ku-follicles eyonakele futhi ibasize ukuba bavuselele. Ngakolunye uhlangothi, i-RU58841 (RU-58841) isebenza ngokubophezela kuma-androgen receptors ezinwele zezinwele. Ngakho-ke ama-androgens awanalo ithuba lokubopha futhi aqale ukusabela kweketango le-androgenetic alopecia futhi aqale inqubo ebizwa ngokuthi i-miniaturization. Kuye kwaboniswa ukuphazamisa endaweni lo mlayezo wokulahlekelwa izinwele ukuze ukukhula kwezinwele okuvamile kuqhubeke.
Isici
(1) Ingavimbela ukulahlekelwa izinwele: I-RU58841 iyi-hormone inhibitor ekhethekile, engavimbela ukuhlanganiswa kwamangqamuzana e-androgen kanye ne-scalp hair follicle, ngaleyo ndlela kunciphise ingozi yokulahlekelwa izinwele.
(2) Ukumuncwa okuhle: I-RU58841 inesisindo esincane samangqamuzana, isakhiwo esilula, futhi kulula ukumunca. Ingangena ngokushesha emzimbeni futhi isebenze ngesikhathi esifushane.
(3) Ukukhetha okuphezulu ku-androgen: I-RU58841 ingavimbela ngokukhetha isenzo se-androgen ngaphandle kokuthinta amanye amahomoni.
(4) Isikhathi eside sesenzo: I-RU58841 inengxenye ende yokuphila emzimbeni, ingavimbela ngokuqhubekayo umphumela we-androgen, futhi isikhathi esisebenzayo singaba amahora angu-48.
(5) Ukuhlanzeka okuphezulu: Ngokukhipha imvelo kanye nenqubo yokukhiqiza emihle, ukuthuthukiswa kwe-RU58841 kungathola imikhiqizo ehlanzekile kakhulu.
Izinhlelo zokusebenza
Ocwaningweni nasezivivinyweni zomtholampilo, i-RU58841 iboniswe ukwandisa izinga lokuphindaphinda kwamangqamuzana kumaseli e-stromal, ukwandisa ukwanda kwamangqamuzana emangqamuzaneni ezimpande zangaphandle kanye nokwandisa ububanzi bezinwele nobuningi bezinwele, ngakho-ke i-RU58841 iyisidakamizwa sophenyo sokwelapha i-androgenetic alopecia. Isimiso esiyinhloko sokusebenza ukuvimbela inhlanganisela ye-DHT ne-AR yezinwele zezinwele, ezivame ukusetshenziselwa ukwelapha ukulahlekelwa izinwele kanye nezinkinga zokulahlekelwa izinwele.
