I-SLU-PP-332 Inombolo ye-CAS: 303760-60-3
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-SLU-PP-332 |
| Elinye igama | I-SLU-PP-332； (E)-4-Hydroxy-N′(Naphthalen-2-Ylmethylene)Benzohydrazide；4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide； |
| Inombolo ye-CAS | 303760-60-3 |
| Ifomula yama-molecule | C18H14N2O2 |
| Isisindo sama-molecule | 290.32 |
| Ubumsulwa | 98% |
| Ukubukeka | Impuphu emhlophe noma engemhlophe |
| Ukupakisha | 1kg/isikhwama, 25kg/ibhareli |
| Isicelo | Isengezo Sokudla Izinto Ezingavuthiwe |
Isingeniso somkhiqizo
I-SLU-PP-332 iyinhlanganisela entsha yama-molecule amancane esebenza njenge-agonist ye-perifollicle estrogen receptor (ERR), egxile kakhulu ku-ERRα, ERRβ, kanye ne-ERRγ, enomphumela onamandla kakhulu wokusebenza ku-ERRα (EC₅₀=98 nM). Le nhlanganisela isebenzisa indlela yokubonisana ye-ERR ngokulingisa izindlela zokulawula umzimba zokuzivocavoca, ngaleyo ndlela iguqule ukusebenza kwamandla, ukusebenza kwe-mitochondrial, kanye nokukhuthazela kwemisipha.
Isici
(1) Indlela yokusebenza: yenza kusebenze i-ERRα/β/γ, khulisa i-fatty acid oxidation (FAO) kanye nezakhi zofuzo ezihlobene nokuphefumula kwe-mitochondrial, kukhuthaza ukuwohloka kwamafutha ukuze kutholakale amandla, kunciphisa ukuqongelela kwamafutha, kuthuthukisa ukusebenza kwe-mitochondrial kwemisipha yamathambo, kuthuthukisa amandla oxidative kanye nokukhuthazela, okufana nomphumela wokuqeqeshwa kwe-aerobic.
(2) Ukusebenza kwe-Bio: a) Imiphumela yemodeli yezilwane: Amagundane akhuluphele: ngemva kwezinsuku ezingu-28 zokusebenzisa imithi, isisindo somzimba sehle ngo-12%, kanti amafutha esibindi, i-cholesterol, kanye ne-triglycerides kwehliswe kakhulu; amagundane avamile: isikhathi sokusebenza sanda ngo-70%, ibanga landa ngo-45%, ngaphandle kokuthinta isifiso sokudla noma ukunyakaza ngokuzithandela. b) Ukuphepha: akukho miphumela emibi engathi sína ebonwe ezifundweni zangaphambi kokwelashwa.
(3) Izakhiwo zomzimba nezamakhemikhali: okumhlophe kuya kokumhlophe okuqinile, okuncibilikayo ku-DMSO (75 mg/mL) kanye ne-ethanol, okungancibiliki emanzini; kufanele kugcinwe ebumnyameni.
Izicelo
I-SLU-PP-332 ifinyelela ekulahlekelweni kwamafutha kanye nokulawulwa kwe-glucose egazini ngokukhuthaza ukushiswa kwamafutha kanye nokuthuthukisa ukuzwela kwe-insulin; ithuthukisa isifo sesibindi esinamafutha esingenalo utshwala (i-NAFLD), inciphisa okuqukethwe kwamafutha esibindi; inikeza ukwesekwa kwe-metabolic kubantu abangakwazi ukuzivocavoca, ukugcina imisipha nokusebenza kwayo; inciphisa ukulahleka kwemisipha ngesikhathi senqubo yokulahlekelwa amafutha; futhi inamathemba abanzi ezindaweni zokulahlekelwa amafutha, ukuthuthukiswa kokukhuthazela, kanye nokuthuthukiswa kwe-metabolic.
