Umkhiqizi wempuphu we-5-Aminolevulinic acid phosphate (ALA) Inombolo ye-CAS: 868074-65-1 Ubumsulwa obungu-98% okungenani ngentengo engcono kakhulu
Ividiyo Yomkhiqizo
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | 5-Aminolevulinic acid phosphate |
| Elinye igama | i-5-amino-4-oxopentanoic acid, i-phosphorus acid; i-5-aminolevulinic acid phosphate, i-5-ALA phosphate; i-5-Amino-4-oxopentanoic acid phosphate; 5-Aminolevulinic acid phosphate; I-Pentanoic acid, i-5-amino-4-oxo-, i-phosphate |
| Inombolo ye-CAS | 868074-65-1 |
| Ifomula yama-molecule | C5H12NO7P |
| Isisindo sama-molecule | 229.13 |
| Ubumsulwa | 98.0% |
| Ukubukeka | Impuphu emhlophe kuya kwemhlophe kakhulu |
| Isicelo | Isengezo Sokudla Izinto Ezingavuthiwe |
Isingeniso somkhiqizo
I-5-Aminolevulinic acid phosphate, eyaziwa kakhulu ngokuthi i-ALA phosphate, iyisihluthulelo esibalulekile ekwakhiweni kwe-heme, ingxenye ebalulekile ye-hemoglobin, i-myoglobin kanye nama-enzyme ahlukahlukene emzimbeni. I-ALA phosphate yenziwa ngochungechunge lwezimpendulo ze-enzyme ezenzeka ikakhulukazi kwi-mitochondria, iziteshi zamandla zamaseli ethu. Yakhiwa kusukela ekuhlanganisweni kwe-glycine kanye ne-succinyl-CoA, okuyizingxenye ezibalulekile zezindlela zethu ze-metabolic. Ukwenziwa kwe-heme kubalulekile empilweni yabantu njengoba le molekyuli idlala indima ebalulekile ekuthuthweni komoya-mpilo, ukudluliselwa kwama-electron kanye nokukhishwa kwe-detox. I-ALA phosphate iyisinyathelo esikhawulela izinga ekwakhiweni kwe-heme. Ngochungechunge lwezinguquko ze-enzymatic, i-ALA phosphate iguqulwa ibe yi-porphobilinogen, i-molecule eyandulela i-heme.
Isici
(1) Ukuhlanzeka okuphezulu: i-5-aminolevulinic acid phosphate ingatholakala njengemikhiqizo yokuhlanzeka okuphezulu ngezinqubo zokukhiqiza ezicwengekile. Ukuhlanzeka okuphezulu kusho ukutholakala okungcono kwe-bioavailability kanye nokusabela okuncane okubi.
(2) Ukuphepha: I-5-aminolevulinic acid phosphate ifakazelwe ukuthi iphephile emzimbeni womuntu.
(3) Ukuzinza: I-5-Aminolevulinic acid phosphate inokuqina okuhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.
Izicelo
I-5-Aminolevulinic acid phosphate (5-ALA) iyi-amino acid yemvelo kanye nesithako esisebenzayo esitholakala kabanzi empilweni. Iyisandulela samakhemikhali e-porphyrin kanye nesisekelo sokusabela kwamakhemikhali kwe-chlorophyll, i-heme kanye ne-vitamin B12. I-5-ALA phosphate isuselwa ku-5-ALA futhi imuncwa kalula futhi isetshenziswe umzimba. Ukuphathwa ngomlomo kwe-5-ALA phosphate kungenza i-myoglobin synthase isebenze, kusheshiswe ukwenziwa kwe-myoglobin emzimbeni womuntu, kwandise amafutha emisipha, futhi kunciphise amafutha. Ngaphezu kwalokho, i-5-ALA ingathuthukisa nomsebenzi we-mitochondria emaseli omuntu, ikhuthaze i-metabolism, ithuthukise ukusebenza kahle kokutholwa kwamandla, futhi inciphise ushukela wegazi kanye nama-lipid egazini. Ekuphetheni, i-5-ALA phosphate iwusizo kakhulu empilweni.
