I-Nefiracetam powder umkhiqizi we-CAS No.: 77191-36-7 99% ubumsulwa min. okwengeza izithako
Ividiyo Yomkhiqizo
Amapharamitha womkhiqizo
| Igama lomkhiqizo | I-Nefiracetam |
| Elinye igama | n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide;NEFIRACETAM; I-2-oxo-1-pyrrolidinylaceticacid, i-2,6-dimethylanilide; dm9384; n-(2,6-dimethylphenyl) -2-oxo-1-pyrrolidineacetamid;DM-9384,(2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide); I-DMMPA |
| Inombolo ye-CAS. | 77191-36-7 |
| Ifomula yamangqamuzana | I-C14H18N2O2 |
| Isisindo samangqamuzana | 246.3 |
| Ubumsulwa | 99.0% |
| Ukubukeka | Impushana emhlophe |
| Ukupakisha | 25 kg/umgqomo |
| Isicelo | i-nootropic |
Isingeniso somkhiqizo
I-Nefiracetam ingeyomndeni we-piracetam, ikilasi lezidakamizwa elaziwa ngezici zazo ezithuthukisa ingqondo. I-Nefiracetam yaqala ukuhlanganiswa ekuqaleni kwawo-1980 futhi yakhanga ngokushesha ngenxa yendlela yayo eyingqayizivele yokusebenza kanye nezinhlelo zokusebenza zokwelapha ezingase zibe khona. Le nhlanganisela ye-racemic kucatshangwa ukuthi ithinta ama-neurotransmitters nama-receptors ebuchosheni, ekugcineni ikhuthaze amakhono okuqonda athuthukisiwe. I-Nefiracetam ngokuyinhloko ithinta amazinga obuchopho e-acetylcholine, i-neurotransmitter eyinhloko ebhekele inkumbulo, ukufunda, nokusebenza kwengqondo. Ngokulungisa ama-acetylcholine receptors, i-nefiracetam ikhuthaza ukuxhumana okwandayo phakathi kwama-neurons, ngaleyo ndlela ithuthukise i-synaptic plasticity futhi ithuthukise ukugcinwa kwenkumbulo. Ukwengeza, i-nefiracetam isebenzisana ne-gamma-aminobutyric acid (GABA) receptors ukusiza ukulinganisa i-neurotransmitter milieu. Ngokuthinta kahle ama-neurotransmitters ajabulisayo futhi avimbelayo, i-nefiracetam isiza ukugcina ukusebenza kahle kobuchopho, ngaleyo ndlela ithuthukise ukugxila, ukunaka, kanye nokusebenza kwengqondo okuphelele.
Isici
(1) Ukuhlanzeka okuphezulu: I-Nefiracetam ingathola imikhiqizo ehlanzekile ngokusebenzisa izinqubo zokukhiqiza zokucwenga. Ukuhlanzeka okuphezulu kusho i-bioavailability engcono kanye nokusabela okungekuhle okumbalwa.
(2) Ukuphepha: Ukuphepha okuphezulu, ukusabela okumbalwa okungekuhle.
(3) Ukuzinza: I-Nefiracetam inokuzinza okuhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezindawo ezihlukene nezimo zokugcina.
Izinhlelo zokusebenza
I-Nefiracetam iyi-hydrophobic derivative ye-piracetam, ngokuvamile ebhekwa njengento enesibopho sokutholakala kweziteshi ze-calcium emzimbeni kanye nokudluliswa okungaqondile kwezinto ezibonisa i-excitatory njenge-agonist ingxenye yeziteshi ze-calcium ion. Indawo ebopha i-Glycine ye-NDMA receptor. Ngomphumela wayo ku-cerebral cortex, i-nefiracetam ingathuthukisa amakhono okuqonda futhi ivimbele ukukhubazeka kokufunda nenkumbulo. Ayinayo i-muscarinic receptor agonist noma izakhiwo eziphikisanayo, futhi ayivimbeli umsebenzi we-acetylcholinease. Ngakho-ke, imiphumela yayo ye-anti-amnestic kanye nenkumbulo yokuthuthukisa itholakala ngokuthuthukisa ukukhululwa kwe-acetylcholine ku-cortex ye-cerebral.
