Umkhiqizi wempuphu ye-YDL223C (HBT1) Inombolo ye-CAS: 489408-02-8 Ubumsulwa obungu-99% obuncane bezithako ezengeziwe
Ividiyo Yomkhiqizo
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-HBT1 |
| Elinye igama | I-YDL223C |
| Inombolo ye-CAS | 489408-02-8 |
| Ifomula yama-molecule | C16H17F3N4O2S |
| Isisindo sama-molecule | 386.40 |
| Ubumsulwa | 99.0% |
| Ukubukeka | Okuqinile okuphuzi okukhanyayo |
| Ukupakisha | 1kg ngesikhwama ngasinye 25kg ngedramu ngayinye |
| Isicelo | izidakamizwa ze-nootropic |
Isingeniso somkhiqizo
I-HBT1 ibopha endaweni yokubopha i-ligand ye-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) ngendlela encike ku-glutamate. Lokhu kusho ukuthi i-HBT1 iyi-molecule engabopha kuphela endaweni ethile ku-AMPA-R protein uma i-glutamate ikhona, futhi lokhu kubopha kusiza ukulawula umsebenzi weprotheni. Ama-receptor e-AMPA abonakala kulo lonke uhlelo lwezinzwa oluphakathi futhi adlala indima ebalulekile ekuxhumaneni kwe-neuronal, ukucubungula izinzwa, ukufunda, inkumbulo, kanye nokuqina kwe-synaptic. Ama-receptor e-AMPA angaba negalelo elikhulu ekudlulisweni kwe-neurotransmission okuvusa imizwa, aqondisa ukuvusa okusheshayo, okusheshayo kuma-synapses amaningi, futhi ahilelekile ekuphenduleni kokuqala kwe-glutamate ezindaweni ze-synaptic. Ama-receptor e-AMPA avame ukuvezwa kanye nama-receptor e-NMDA kuma-synapses, futhi ndawonye akhuthaza izinqubo ze-synaptic plasticity ezihilelekile ekufundeni, enkumbulo, ekuvuseleleni imizwa, kanye nasekuvikeleni imizwa. I-neurotrophic factor etholakala ebuchosheni (i-BDNF) iyisici se-neurotrophic esidlala indima ebalulekile ekugcinweni nasekukhuleni kwama-neuron futhi inemiphumela enamandla neningi ekwandeni, ekuhlukaniseni, ekusindeni nasekufeni kwamaseli e-neuronal kanye nalawo angewona ama-neuronal. , i-neurotransmitter modulator enegalelo ekuqineni kwama-neuron ekufundeni nasekukhumbuleni. Ngakho-ke, ibalulekile empilweni nasenhlalakahleni yesimiso sezinzwa.
Isici
(1) Ubumsulwa obuphezulu: I-HBT1 ingathola imikhiqizo ehlanzekile kakhulu ngezinqubo zokukhiqiza zokucwenga. Ubumsulwa obuphezulu busho ukutholakala okungcono kwe-bioavailability kanye nokusabela okuncane okubi.
(2) Ukuphepha: I-HBT1 ifakazelwe ukuthi iphephile emzimbeni womuntu.
(3) Ukuzinza: I-HBT1 inokuqina okuhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.
Izicelo
I-HBT1 iyisithuthukisi esisha se-AMPA receptor esine-agonism ephansi, esibangela ukukhiqizwa kwe-neurotrophic factor (BDNF) etholakala ebuchosheni futhi inemiphumela emincane ye-agonistic kuma-neuron ayisisekelo. I-HBT1 ibopha endaweni ye-AMPA-R ebopha i-ligand ngendlela encike ku-glutamate. Ndawonye, ikhuthaza izinqubo ze-synaptic plasticity ezihilelekile ekufundeni, ekukhumbuleni, ekujabuleni, nasekuvikeleni i-neuroprotection. Ingathuthukisa ikhono lobuchopho lokuqonda kanye nenkumbulo, futhi ithuthukise ikhono lokufunda labantu. Ngokuvamile ingezwa ekudleni kwansuku zonke ngesimo sezithako zokudla.
