I-Oleoylethanolamide (OEA) umkhiqizi we-powder CAS No.: 111-58-0 98%,85% ubumsulwa min. okwengeza izithako
Amapharamitha womkhiqizo
| Igama lomkhiqizo | I-Oleoyl ethanolamide |
| Elinye igama | I-N-oleoyl ethanolamine; N-(2-hydroxyethyl)-,(Z)-9-Octadecenamide |
| Inombolo ye-CAS. | 111-58-0 |
| Ifomula yamangqamuzana | I-C20H39NO2 |
| Isisindo samangqamuzana | 325.53 |
| Ubumsulwa | 98.0%, 85.0% |
| Ukubukeka | I-crystal powder emhlophe |
| Ukupakisha | 1kg/isikhwama, 25kg/isigubhu |
| Isicelo | Ukunciphisa ubuhlungu, anti-inflammatory |
Isingeniso somkhiqizo
I-Oleoylethanolamide iyinhlanganisela yesibili ye-amide eyakhiwe i-lipophilic oleic acid ne-hydrophilic ethanolamine. I-Oleoylethanolamide nayo iyi-molecule ye-lipid eyenzeka ngokwemvelo kwezinye izicubu zezilwane nezitshalo. Itholakala kakhulu ezicutshini zezilwane nezitshalo ezifana ne-cocoa powder, ubhontshisi wesoya namantongomane, kodwa okuqukethwe kwayo kuphansi kakhulu. Kuphela lapho imvelo yangaphandle ishintsha noma ukudla kukhuthazwa, izicubu zamangqamuzana omzimba Kungaleso sikhathi kuphela lapho kuyokhiqizwa okwengeziwe kwalokhu.
Ezingeni lokushisa legumbi, i-Oleoylethanolamide iqinile emhlophe enephuzu lokuncibilika cishe elingu-50°C. Incibilika kalula kuzincibilikisi zotshwala ezifana ne-methanol ne-ethanol, incibilika kalula kuzincibilikisi ezingezona ze-polar njenge-n-hexane ne-ether, futhi ayincibiliki emanzini. I-OEA i-amphiphilic molecule ngokuvamile esetshenziswa njenge-surfactant kanye ne-detergent embonini yamakhemikhali. Kodwa-ke, ucwaningo olwengeziwe lwathola ukuthi i-OEA ingasebenza njengengqamuzana elibonisa i-lipid ku-axis yobuchopho futhi ibonise uchungechunge lwemisebenzi yebhayoloji emzimbeni, okuhlanganisa: ukulawula isifiso sokudla, ukuthuthukisa i-lipid metabolism, ukuthuthukisa inkumbulo nokuqonda kanye neminye imisebenzi. Phakathi kwazo, imisebenzi ye-Oleoylethanolamide yokulawula ukudla kanye nokwenza ngcono i-lipid metabolism ithole ukunakwa kakhulu.
I-Oleoylethanolamide ingalawula ukudla kanye ne-homeostasis yamandla ngokuvula i-peroxisome proliferator-activated receptor-α. Ngaphezu kwalokho, i-Oleoylethanolamide ibonisa eminye imisebenzi ehlobene nempilo, okuhlanganisa ukumodulating umsebenzi wokuguqula endleleni yokubonisa i-lysosomal-to-nuclear ehambisana nokulawulwa kokuphila isikhathi eside nokuvikela izinzwa ezilawula ukuziphatha okucindezelayo. Ucwaningo luphinde luveze ukuthi i-Oleoylethanolamide ingaba nemiphumela ye-neuroprotective. Emamodeli ezilwane, kutholwe ukunciphisa umonakalo osuka ekushayweni nasekulinyazweni okubuhlungu kobuchopho. Umphumela olawulayo we-Oleoylethanolamide ubangelwa ukubopha kwayo ku-PPARα, encipha nge-retinoid X receptor (RXR) futhi iyenze isebenze njengento enamandla yokubhala ehilelekile ekuhlanganisweni kwe-homeostasis yamandla, i-lipid metabolism, i-autophagy, nokuvuvukala. okuhlosiwe komfula.
Isici
(1) Ukuhlanzeka okuphezulu: I-OEA ingathola imikhiqizo ehlanzekile ngezinqubo zokukhiqiza zokucwenga. Ukuhlanzeka okuphezulu kusho i-bioavailability engcono kanye nokusabela okungekuhle okumbalwa.
(2) Ukuphepha: I-OEA ifakazelwe ukuthi iphephile emzimbeni womuntu.
(3) Ukuzinza: I-OEA inokuzinza okuhle futhi ingagcina umsebenzi wayo nomthelela ngaphansi kwezimo ezihlukene nezimo zokulondoloza.
(4) Kulula ukumunca: I-OEA ingamuncwa ngokushesha umzimba womuntu futhi isatshalaliswe ezicutshini nasezithweni ezahlukene.
Izinhlelo zokusebenza
I-Oleoylethanolamide iyi-lipid yemvelo ye-ethanolamide esetshenziswa njengohlelo lokudla kanye nokulawula isisindo somzimba ezinhlobonhlobo zezilwane ezinomgogodla. Kuyi-metabolite ye-oleic acid eyakhiwe emathunjini amancane omuntu. I-Oleylethanolamide (OEA) iyi-molecule elawula i-lipid metabolism kanye ne-homeostasis yamandla. Inamathela kuma-receptors e-PPAR Alpha futhi isiza ukulawula izici ezine: indlala, amafutha omzimba, i-cholesterol nesisindo. I-PPAR Alpha imele i-peroxide proliferator-activated receptor alpha, futhi i-bioactive lipid amide oleoylethanolamide (OEA) inezinto ezihlukahlukene eziyingqayizivele ze-homeostatic, ezihlanganisa umsebenzi wokulwa nokuvuvukala, ukuguqulwa kwe-immune impendulo, kanye nemiphumela ye-antioxidant.
