Umkhiqizi wempuphu we-PRL-8-53 Inombolo ye-CAS: 51352-87-5 Ubumsulwa obungu-98% obuncane bezithako ezengeziwe
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-PRL-8-53 |
| Elinye igama | I-Methyl 3-(2-(benzyl(Methyl)aMino)ethyl)benzoate hydrochloride；Benzoic acid, 3-[2-[methyl(phenylmethyl)amino]ethyl]-, i-methyl ester, i-hydrochloride (1:1)；I-Methyl 3-{2-[benzyl(methyl)amino]ethyl}benzoate hydrochloride (1:1) |
| Inombolo ye-CAS | 51352-87-5 |
| Ifomula yama-molecule | C18H22I-ClNO2 |
| Isisindo sama-molecule | 319.83 |
| Ubumsulwa | 98.0% |
| Ukubukeka | Impuphu emhlophe |
| Ukupakisha | 1 kg ngesikhwama ngasinye 25kg/isigubhu |
| Isicelo | i-nootropic |
Isingeniso somkhiqizo
I-PRL-8-53, eyaziwa nangokuthi i-methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate, iyinhlanganisela ye-nootropic yokwenziwa ecatshangwa ukuthi ithuthukisa ukudluliselwa kwe-cholinergic futhi ilawula amazinga e-dopamine ebuchosheni. Lokhu kuziphatha kunegalelo emiphumeleni yayo engaba ngcono yokuqonda, ngaleyo ndlela ithuthukise ukwakheka kwenkumbulo, ukugcinwa, kanye nokubuyisa. Izifundo eziningi ezilwaneni nakubantu zibike imiphumela emihle yezakhiwo zayo zokuthuthukisa inkumbulo. Esifundweni sokuhlola esilawulwa yi-placebo esingaboni kabili, abantu abathole umthamo owodwa we-PRL-8-53 babonise amakhono angcono okukhumbula amagama kanye nokubuyisa uma kuqhathaniswa neqembu le-placebo. Lokhu okutholakele kwavusa isithakazelo kanye nocwaningo olwengeziwe mayelana namandla enhlanganisela. Olunye ucwaningo kumagundane lubonise ukuthi ukunikeza i-PRL-8-53 kuthuthukise kakhulu ikhono labo lokufunda emsebenzini we-maze wamanzi. Amagundane aphathwe nge-PRL-8-53 akwazile ukuthola ipulatifomu efihliwe kahle kakhulu kunezilawuli, okubonisa amandla enhlanganisela njengesithuthukisi senkumbulo.
Isici
(1) Ubumsulwa obuphezulu: I-PRL-8-53 ingathola imikhiqizo yobumsulwa obuphezulu ngezinqubo zokukhiqiza zokucwenga. Ubumsulwa obuphezulu busho ukutholakala okungcono kwe-bioavailability kanye nokusabela okuncane okubi.
(2) Ukuphepha: Ukuphepha okuphezulu, ukusabela okungekuhle okumbalwa, akukho ukusabela okungekuhle okusobala.
(3) Ukuzinza: I-PRL-8-53 inokuqina okuhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.
Izicelo
Njengohlobo olusha lwesengezo sokuthuthukisa ingqondo, i-PRL-8-53 ithuthukisa inkumbulo yesikhashana kanye nenkumbulo yokusebenza, ngenkathi ithuthukisa ikhono lokufunda kanye nesivinini sokuthola amakhono, isiza ekuthuthukiseni ukufunda nokusebenza kahle. Ucwaningo lubonisa ukuthi i-PRL-8-53 ingakhuthaza ukukhula nokuvuselelwa kwama-neurons ebuchosheni. I-PRL-8-53 ingandisa isivinini lapho ubuchopho bucubungula khona ulwazi, ivumela abantu ukuthi baqedele imisebenzi futhi benze izinqumo ngokushesha. Nakuba iqhathaniswa nezinye izinhlanganisela ze-nootropic Kodwa-ke, ucwaningo nge-PRL-8-53 lulinganiselwe, kodwa ucwaningo olukhona lubonisa amandla alo ekuthuthukiseni inkumbulo kanye namakhono okuqonda.
