Umkhiqizi wempuphu we-RU58841 Inombolo ye-CAS: 154992-24-2 Ubumsulwa obungu-99.0% obuncane bezithako ezengeziwe
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile |
| Elinye igama | RU58841 |
| Inombolo ye-CAS | 154992-24-2 |
| Ifomula yama-molecule | C17H18F3N3O3 |
| Isisindo sama-molecule | 369.34 |
| Ubumsulwa | 99.0% |
| Ukubukeka | impuphu emhlophe |
| Ukupakisha | 1kg/isikhwama |
| Isicelo | Khulisa izinwele |
Isingeniso somkhiqizo
I-RU58841 (eyaziwa nangokuthi i-RU-58841) iyinhlanganisela, i-RU58841 incintisana ne-dihydrotestosterone ukugcina amazinga e-DHT ngaphakathi kwebanga elijwayelekile, ngaleyo ndlela ilawula umjikelezo wokukhula kwezinwele. Ivuselela ukuguqulwa kwama-follicle ezinwele amasha abe ama-follicle ezinwele e-anagen ngokungena esigabeni se-anagen. Ukuvumela ama-follicle alimele isikhathi sokushintshela esigabeni sokukhula esijwayelekile kusiza amaseli ukuthi alulame. Iphinde ikhulise ukugeleza kwegazi kuma-follicle alimele futhi iwasize aphinde avuseleleke. Ngakolunye uhlangothi, i-RU58841 (RU-58841) isebenza ngokubopha kuma-receptor e-androgen kuma-follicle ezinwele. Ngakho ama-androgen awanayo ithuba lokubopha nokuqala ukusabela kwe-chain ye-androgenetic alopecia nokuqala inqubo ebizwa ngokuthi i-miniaturization. Kuye kwabonakala ukuthi kuphazamisa lo myalezo wokulahlekelwa izinwele endaweni ukuze ukukhula kwezinwele okuvamile kuqhubeke.
Isici
(1) Ingavimbela ukulahleka kwezinwele: I-RU58841 iyi-hormone inhibitor ekhethekile, engavimbela ukuhlanganiswa kwamaseli e-androgen kanye ne-scalp hair follicle, ngaleyo ndlela inciphise ingozi yokulahleka kwezinwele.
(2) Ukumunca okuhle: I-RU58841 inesisindo esincane sama-molecule, isakhiwo esilula, futhi kulula ukuyimunca. Ingangena ngokushesha emzimbeni futhi isebenze ngesikhathi esifushane.
(3) Ukukhetha okuphezulu kwe-androgen: I-RU58841 ingavimbela ngokukhetha isenzo se-androgen ngaphandle kokuthinta amanye ama-hormone.
(4) Isikhathi eside sokusebenza: I-RU58841 inokuphila okuyingxenye emzimbeni isikhathi eside, ingavimbela njalo umphumela we-androgen, futhi isikhathi esisebenzayo singaba amahora angama-48.
(5) Ubumsulwa obuphezulu: Ngokukhipha izinto zemvelo kanye nenqubo yokukhiqiza izinto ezincane, ukuthuthukiswa kwe-RU58841 kungathola imikhiqizo ehlanzekile kakhulu.
Izicelo
Ocwaningweni nasezivivinyweni zemitholampilo, i-RU58841 iboniswe ukuthi ikhulisa izinga lokuphindaphindeka kwamaseli kumaseli e-stromal, yandisa ukwanda kwamaseli kumaseli eshidi lempande langaphandle futhi yandisa ububanzi bezinwele kanye nobuningi bezinwele, ngakho-ke i-RU58841 iyisidakamizwa sokucwaninga sokwelapha i-androgenetic alopecia. Isimiso esiyinhloko esisebenzayo ukuvimba inhlanganisela ye-DHT kanye ne-AR yama-follicle ezinwele, okuvame ukusetshenziselwa ukwelapha izinkinga zokulahlekelwa izinwele kanye nokulahlekelwa izinwele.
