5-Amino-1-methylquinolinium iodide（NNMTi） Inombolo ye-CAS:42464-96-0 ubumsulwa obungu-98.0% ubuncane | umenzi wezithako ezengeziwe
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-5-Amino-1-methylquinolinium iodide（NNMTi） |
| Elinye igama | I-NNTiI-5-AMINO-1-METHYLQUINOLIN-1-IUM IODAYIDE i-5-amino-1-methylquinolinium iodide 5-Amino-1-methylquinolin-1-iumiodide i-1-methylquinolin-1-ium-5-amine; iodide I-5-Amino-1-methyl-1-quinolinium Iodide iodide engu-5-Amino-1-mq |
| Inombolo ye-CAS | 42464-96-0 |
| Ifomula yama-molecule | C10H11IN2 |
| Isisindo sama-molecule | 286.11 |
| Ubumsulwa | 98.0% |
| Ukubukeka | Okuqinile okunsundu kuya kokubomvu |
| Ukupakisha | 1kg/isikhwama, 25kg/ibhareli |
| Isicelo | Isengezo Sokudla Izinto Ezingavuthiwe |
Isingeniso somkhiqizo
I-enzyme ye-cytosolic i-nicotinamide N-methyltransferase (NNMT) isanda kutholwa ukulawula amazinga ezinto ezandulela i-nicotinamide ezidingekayo kwi-biosynthesis ye-NAD+ ngakho-ke idlala indima ebalulekile ekulawuleni indlela yokusindisa i-NAD+ kanye ne-metabolism yamaseli. I-NNMT ivezwa emisipheni yamathambo, futhi ukubonakaliswa kwayo kuyanda kancane kancane ngokuguga kwezicubu zemisipha. Okubalulekile, i-NNMT iyisici esiyinhloko sesiginesha yokubonakaliswa kwezakhi zofuzo ze-sarcopenic, futhi ukuvezwa kwayo ngokweqile kungaholela ekwehleni okukhulu kwamazinga e-NAD+ kanye nokwehla kwesisindo semisipha, amandla, kanye nomsebenzi ohambisana nokuguga. Ukwelashwa kwamagundane asebekhulile nge-molecule encane i-NNMT inhibitor (NNMTTi) kuthuthukise ukwanda, ukuhlanganiswa, kanye namandla okuvuselela ama-muSC, ngaleyo ndlela kuthuthukiswe ukusebenza kwemisipha yamathambo. Imiphumela efanayo itholakale ku-vitro kusetshenziswa amaseli e-C2C12, afana kakhulu nama-muSC, lapho ukwelashwa kwe-NNMTTi kukhuthaze ukuhlukaniswa kwe-myoblast futhi kusekele izinguquko ze-metabolic kuma-metabolites amaseli ahlobene nendlela yokusindisa i-NAD +.
I-NNMT iyi-enzyme evezwa kakhulu ngesikhathi sokuguga kwemisipha yamathambo futhi ihlotshaniswa nomonakalo endleleni ye-NAD+, umsebenzi we-sirtuin1 ongalawulwa kahle, kanye nokukhula kwe-muscle stem cell. I-NNMT iyi-enzyme ye-metabolic evuselela i-methylation ye-nicotinamide (NAM) isebenzisa i-universal methyl donor S-adenosylmethionine (SAM), exhumanisa isimo se-metabolic seseli nebhalansi ye-methylation kanye namazinga e-NAD+ angaphakathi kweseli. I-NNMT ivezwa kakhulu ezicutshini zesibindi ne-adipose, kanye nasezimweni ze-pathological ezibonakala ngezidingo ezengeziwe ze-metabolic, njengezifo ezithile zesibindi esinamafutha nesifo sikashukela. I-NNMT ihilelekile ezinqubweni ezahlukahlukene zokuhlukanisa, kufaka phakathi ukuguquka kwe-stem cell yomuntu ovuthiwe, i-myogenesis, kanye nokuguquka kwe-epithelial kanye ne-neuromesenchymal kumdlavuza ohlukahlukene. Ukuvezwa kwe-NNMT kulawulwa ngendlela ethile yezicubu nomongo kunokuba kube yiphethini yokulawula etholakala yonke indawo.
Isici
(1) Ubumsulwa obuphezulu: I-NNMTi ingathola imikhiqizo ehlanzekile kakhulu ngezinqubo zokukhiqiza ezicwengekile. Ubumsulwa obuphezulu busho ukutholakala okungcono kwezinto eziphilayo.
(2) Ukuqondisa: I-NNMTTi ihlose ngqo i-enzyme ye-NNMT futhi ingavimbela ngempumelelo umsebenzi wayo, ngaleyo ndlela ithinte indlela ye-metabolic ye-nicotinamide.
(3) Ukuzinza: I-NNMTi inokuqina okuhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.
(4) Amathemba okuthuthuka: Ngenxa yezici ezahlukahlukene ze-NNMTi, intuthuko yayo ithole ukunakwa kabanzi futhi inocwaningo olubanzi kanye namathemba okusetshenziswa.
Izicelo
I-NNMT (CAS 42464-96-0) iyisivimbeli se-nicotinamide N-methyltransferase (NNMT), isivimbeli esinamandla (IC50=1.2 μM) se-nicotinamide N-methyltransferase (NNMT) esikhuthaza ukwahlukaniswa kwe-myoblast. I-NNMTTi ibopha ngokukhetha izinsalela zesayithi lokubopha i-NNMT substrate. I-NNMTTi ikhuthaza ukwahlukaniswa kwe-myoblast in vitro futhi ithuthukisa ukuhlanganiswa kwamaseli e-muscle stem kanye nokuvuselelwa kwamagundane asebekhulile. I-NNMT iyi-enzyme eyisisekelo ye-cytosolic biotransformation ekhuthaza i-N-methylation yama-xenobiotics angaphandle nangaphandle. Uma kuqhathaniswa nokufakwa esikhundleni sokudla okungenamafutha kuphela, ukwelashwa kwe-NNMTTi kuhlanganiswe nokufakwa esikhundleni sokudla okungenamafutha kwasheshisa ukuthuthuka kokulahlekelwa kwamafutha emzimbeni, kwandise isisindo somzimba wonke kuya esilinganisweni sesisindo somzimba, kuncishiswe isisindo sezicubu ezimhlophe ze-epididymal yesibindi, kuncishiswe ukufakwa kwamafutha esibindi, kanye nokuthuthukiswa kwe-steatosis yesibindi. Ngaphezu kwalokho, i-NNMT ingandisa amandla futhi ikhuthaze amandla okuvuselela emisipha esebekhulile, okungaba usizo ekwelapheni i-sarcopenia.
