Umkhiqizi wempuphu ye-J-147 Inombolo ye-CAS: 1146963-51-0 Ubumsulwa obungu-99.0% obuncane bezithako ezengeziwe
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide] |
| Elinye igama | J-147, J147 |
| Inombolo ye-CAS | 1146963-51-0 |
| Ifomula yama-molecule | C18H17F3N2O2 |
| Isisindo sama-molecule | 350.33 |
| Ubumsulwa | 99% |
| Ukubukeka | Impuphu emhlophe |
| Ukupakisha | 1kg ngesikhwama ngasinye |
| Isicelo | izidakamizwa ze-nootropic |
Isingeniso Somkhiqizo
I-J-147 iyi-neuroprotective enamandla kakhulu esetshenziswa ngomlomo etholakala ngokuyinhloko ku-curcumin, isithako esisebenzayo ku-turmeric. Ngokungafani ne-curcumin, idlula umgoqo wegazi nobuchopho ngempumelelo enkulu. Phakathi kwazo, i-J-147 isebenza ngokubopha ku-ATP synthase. Ukukhiqizwa ngokweqile kwe-ATP kuhlotshaniswa nenqubo yokuguga. Ngaphezu kokwandisa amazinga e-neurotransmitters i-NGF ne-BDNF, i-J-147 ingalawula lokhu. Ngaphezu kwalokho, i-J-147 ivimbela i-monoamine oxidase B kanye ne-dopamine transporter. Ikhuthaza ukukhula kobuchopho ngokwandisa amazinga e-nerve growth factor (NGF) kanye ne-brain-derived neurotrophic factor (BDNF). Okubaluleke kakhulu, i-J-147 ingakhuthaza ukukhula kwamaseli amasha e-nerve, ithuthukise ikhono lokufunda lobuchopho kanye nenkumbulo, futhi ithuthukise ukusebenza kwengqondo.
Isici
(1) Ubumsulwa obuphezulu: I-J-147 ingathola imikhiqizo yobumsulwa obuphezulu ngezinqubo zokukhiqiza zokucwenga. Ubumsulwa obuphezulu busho ukutholakala okungcono kwe-bioavailability kanye nokusabela okuncane okubi.
(2) Ukuphepha: I-J-147 ifakazelwe ukuthi iphephile emzimbeni womuntu.
(3) Ukuzinza: I-J-147 inokuqina okuhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.
(4) Kulula ukumunca: I-J-147 ingamuncwa ngokushesha ngumzimba womuntu, ingene ekujikelezeni kwegazi ngamathumbu, futhi isatshalaliswe ezicutshini nasezithweni ezahlukene.
Izicelo
I-J-147 iyinhlanganisela yokwenziwa enomsebenzi wayo oyinhloko wokusebenza ohilela ukuthuthukiswa kwe-mitochondrial, ngaleyo ndlela ithuthukise ukukhiqizwa kwamandla ezingeni lamaseli. I-J-147 yenzelwe ukuthuthukisa ikhono lobuchopho lokuzilungisa nokuzivikela ekulimaleni okuhlobene nokuguga ngokuthuthukisa ukusebenza kwe-mitochondrial. Ngaphezu kwalokho, i-J-147 ikhombisa izakhiwo ezibalulekile zokulwa nokuvuvukala kanye ne-antioxidant, ithuthukisa kakhulu imiphumela yayo engaba khona yokuvikela izinzwa. I-J-147 ingakhuthaza ukukhula kwamaseli amasha ezinzwa, ithuthukise ikhono lokufunda lobuchopho kanye nenkumbulo, futhi ithuthukise ukusebenza kwengqondo.
