I-Lemairamin (WGX-50) umkhiqizi we-powder CAS No.: 29946-61-0 98.0% ubumsulwa min.okwengeza izithako
Amapharamitha womkhiqizo
| Igama lomkhiqizo | I-Lemairamin |
| Elinye igama | 2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; I-Lemairamin (WGX-50) |
| Inombolo ye-CAS. | 29946-61-0 |
| Ifomula yamangqamuzana | I-C19H21NO3 |
| Isisindo samangqamuzana | 311.37 |
| Ubumsulwa | 98.0% |
| Ukubukeka | Impushana emhlophe ukuya kokumhlophe |
| Isicelo | I-Dietary Supplement Raw Material |
Isingeniso somkhiqizo
I-Lemairamin noma i-Wgx50 iyinhlanganisela yemvelo ekhishwe kupelepele obonise imiphumela ethembisayo ekuvimbeleni isifo i-Alzheimer's.Ucwaningo luthole ukuthi lungavimbela i-Aβ-induced neuronal apoptosis, lwehlise ubuthi be-neuronal calcium, futhi lwehlise ukunqwabelana kwama-oligomers e-Aβ ku-cerebral cortex.Ngokwengeziwe, i-wgx50 iboniswe ukuthuthukisa ukusebenza kwengqondo kumagundane.Ucwaningo luphakamisa ukuthi i-wgx50 inamandla okuvimbela ukuhlangana kwamaprotheni-namaprotheni phakathi kwama-amyloid molecule.Sekukonke, i-wgx50 inamandla okuvimbela isifo se-Alzheimer futhi ingase inikeze izindlela ezintsha zokuthuthukiswa kwezidakamizwa eziqondiswe kuma-Aβ oligomers.Ukwengeza, i-WGX-50 ibonisa umsebenzi obalulekile wokulwa nokuvuvukala, okwenza kube ikhandidethi elithembisayo lokwelapha izifo ezivuthayo.I-WGX-50 itholwe inemiphumela ephawulekayo esikhumbeni, njengokunciphisa imibimbi nokuthuthukisa ukunwebeka kwesikhumba.Ngaphezu kwezinhlanganisela zemvelo ezikhishwe esitshalweni i-Zanthoxylum bungeanum, okwamanje kunezinhlanganisela zokwenziwa ezengeziwe ezisetshenziswa ezinhlelweni ezahlukahlukene futhi ezifaneleke kakhulu emakethe.
Isici
(1) Ukuhlanzeka okuphezulu: I-Lemairamin ingathola imikhiqizo ehlanzekile ngokusebenzisa isizinda semvelo kanye nezinqubo zokukhiqiza zokucwenga.Ukuhlanzeka okuphezulu kusho i-bioavailability engcono kanye nokusabela okungekuhle okumbalwa.
(2) Ukuphepha: Ukuphepha okuphezulu, ukusabela okubi okumbalwa, akukho ukusabela okubi okusobala ngisho nangokusetshenziswa isikhathi eside.
(3) Ukuzinza: I-Lemairamin inokuzinza okuhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezindawo ezihlukene nezimo zokugcina.
(4) Kulula ukumunca: I-Lemairamin ingamuncwa ngokushesha umzimba womuntu futhi isatshalaliswe ezicutshini nasezithweni ezahlukene.
Izinhlelo zokusebenza
I-Lemairamin iyinhlanganisela ye-amide ekhishwe egxolweni lesitshalo se-Zanthoxylum bungeanum.Njengamanje isetshenziswa njengesengezo sokudla, iphinde isebenze njenge-agonist ye-alpha7 nicotinic acetylcholine receptor (α7nAChR), eyehlisa i-neuroinflammation esifo se-Alzheimer's, futhi isenziwa ngokuphelele.I-Wgx50 ibonise imiphumela ekhuthazayo ezifundweni zangaphambi komtholampilo, okuhlanganisa ukuvimbela i-Aβ-induced neuronal i-apoptosis, inciphisa ubuthi be-neuronal calcium, inciphisa ukunqwabelana kwama-oligomers e-Aβ ku-cerebral cortex, nokuthuthukisa ukusebenza kwengqondo kumagundane.
