Umkhiqizi wempuphu i-Lemairamin (WGX-50) Inombolo ye-CAS: 29946-61-0 Ubumsulwa obungu-98.0% obuncane bezithako ezengeziwe
Ividiyo Yomkhiqizo
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-Lemairamin |
| Elinye igama | 2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; I-Lemairamin (WGX-50) |
| Inombolo ye-CAS | 29946-61-0 |
| Ifomula yama-molecule | C19H21NO3 |
| Isisindo sama-molecule | 311.37 |
| Ubumsulwa | 98.0% |
| Ukubukeka | Impuphu emhlophe kuya kwemhlophe kakhulu |
| Isicelo | Isengezo Sokudla Izinto Ezingavuthiwe |
Isingeniso somkhiqizo
I-Lemairamin noma i-Wgx50 iyinhlanganisela yemvelo ekhishwe kupelepele ophuzi ebonise imiphumela ethembisayo ekuvimbeleni isifo i-Alzheimer's. Izifundo zithole ukuthi ingavimbela i-apoptosis ye-neuronal ebangelwa yi-Aβ, inciphise ubuthi be-calcium ye-neuronal, futhi inciphise ukuqongelela kwama-oligomers e-Aβ ku-cortex yobuchopho. Ngaphezu kwalokho, i-wgx50 iboniswe ukuthi ithuthukisa ukusebenza kwengqondo emagundwini. Ucwaningo lusikisela ukuthi i-wgx50 inamandla okuvimbela ukuhlangana kwamaprotheni namaphrotheni phakathi kwama-molecule e-amyloid. Sekukonke, i-wgx50 inamandla okuvimbela isifo i-Alzheimer's futhi ingahlinzeka ngezindlela ezintsha zokuthuthukiswa kwemithi ehlose ama-oligomers e-Aβ. Ngaphezu kwalokho, i-WGX-50 ibonisa umsebenzi obalulekile wokulwa nokuvuvukala, okwenza kube yinto ethembisayo yokwelapha izifo zokuvuvukala. I-WGX-50 itholakale inemiphumela ebalulekile esikhumbeni, njengokunciphisa imibimbi nokuthuthukisa ukuqina kwesikhumba. Ngaphezu kwamakhemikhali emvelo akhishwe esitshalweni i-Zanthoxylum bungeanum, okwamanje kunezinye izinto zokwenziwa ezisetshenziswa ezindaweni ezahlukahlukene futhi ezifaneleka kakhulu emakethe.
Isici
(1) Ukuhlanzeka okuphezulu: I-Lemairamin ingathola imikhiqizo ehlanzeka kakhulu ngokusebenzisa izinqubo zokukhiqiza zemvelo kanye nokucwenga. Ukuhlanzeka okuphezulu kusho ukutholakala okungcono kwe-bioavailability kanye nokusabela okuncane okubi.
(2) Ukuphepha: Ukuphepha okuphezulu, ukusabela okumbalwa okubi, akukho ukusabela okusobala okubi ngisho noma kusetshenziswa isikhathi eside.
(3) Ukuzinza: I-Lemairamin inokuqina okuhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.
(4) Kulula ukumunca: I-Lemairamin ingamuncwa ngokushesha ngumzimba womuntu futhi isatshalaliswe ezicutshini nasezithweni ezahlukene.
Izicelo
I-Lemairamin iyi-amide compound ekhishwe egxolweni lesitshalo se-Zanthoxylum bungeanum. Njengamanje isetshenziswa njengesengezo sokudla, isebenza futhi njenge-agonist ye-alpha7 nicotinic acetylcholine receptor (α7nAChR), enciphisa ukuvuvukala kwe-neuroinflammation kwisifo i-Alzheimer's, futhi yenziwe ngokuphelele. I-Wgx50 ibonise imiphumela ekhuthazayo ezifundweni zangaphambi kokwelashwa, okuhlanganisa ukuvimbela i-apoptosis ye-neuronal ebangelwa yi-Aβ, ukunciphisa ubuthi be-calcium ye-neuronal, ukunciphisa ukuqongelela kwama-oligomers e-Aβ ku-cortex yobuchopho, kanye nokuthuthukisa ukusebenza kwengqondo kumagundane.
