Umkhiqizi wempuphu we-CMS121 Inombolo ye-CAS: 1353224-53-9 Ubumsulwa obungu-98.0% obuncane bezithako ezengeziwe
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-CMS121 |
| Elinye igama | I-CMS-121; 1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); I-ACC, i-AcetylCoenzymeACarboxylase, isifo, ukuvikela imizwa, ukuvimbela, ukulwa nokuvuvukala, i-mitochondrial, i-Alzheimer's, i-antioxidative, i-acetylation, i-Inhibitor, i-H3K9, i-Acetyl-CoACarboxylase, i-CMS121, i-dementia, i-ACC1, i-CMS-121 |
| Inombolo ye-CAS | 1353224-53-9 |
| Ifomula yama-molecule | C20H19NO3 |
| Isisindo sama-molecule | 321.37 |
| Ubumsulwa | 98.0% |
| Ukubukeka | Impuphu ephuzi ekhanyayo |
| Isicelo | Isengezo Sokudla Izinto Ezingavuthiwe |
Isingeniso somkhiqizo
I-4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol iyinhlanganisela ebizwa nangokuthi i-CMS121. Ubunzima besakhiwo senhlanganisela busikisela ukuthi ingaba nezakhiwo ezihlukile kanye nokusetshenziswa okungenzeka. Ukuze uqonde ukubaluleka kwayo, kusiza ukuhlonza amaqembu asebenzayo akhona futhi kuhlaziywe umthelela wawo ongaba khona. Ukuba khona kwendandatho ye-quinoline kusikisela ukuthi inhlanganisela ingase isebenze ngokwezinto eziphilayo. Ama-molecule atholakala ku-Quinoline aziwa ngezakhiwo zawo ezihlukahlukene zezinto eziphilayo, okuhlanganisa imisebenzi yokulwa namagciwane kanye neyokulwa nokuvuvukala. Ukunamathela kweqembu le-cyclopentyloxy kungasiza ekuncibilikeni kwenhlanganisela noma kuthuthukise umsebenzi wayo wezinto eziphilayo ngemiphumela ye-steric. Ezifundweni zamaseli e-HT22, i-CMS-121 ibonise imiphumela ebalulekile yokuvikela izinzwa, ivikela ngempumelelo la maseli ekulimaleni kwe-ischemia kanye ne-oxidative. Ngaphezu kwalokho, i-CMS-121 inezakhiwo ezibalulekile zokulwa nokuvuvukala, okubonisa ikhono layo lokulawula izimpendulo zokuvuvukala. Ngokwenza kanjalo, i-CMS-121 inamandla okunciphisa ukuvuvukala ezicutshini nasezithweni ezahlukahlukene. I-CMS-121 inomsebenzi omkhulu wezokwelapha njengesivimbeli se-acetyl-CoA carboxylase 1 (ACC1). Umphumela wayo onamandla wokuvimbela ku-ACC1 uyenza ibe yikhompawundi ethembisayo.
Isici
(1) Ukuhlanzeka okuphezulu: I-CMS-121 ingathola imikhiqizo ehlanzeka kakhulu ngezinqubo zokukhiqiza ezicwengekile. Ukuhlanzeka okuphezulu kusho ukutholakala okungcono kwe-bioavailability kanye nokusabela okuncane okubi.
(2) Ukuphepha: Ukuphepha okuphezulu, ukusabela okungekuhle okumbalwa.
(3) Ukuzinza: I-CMS-121 inozinzo oluhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.
Izicelo
I-CMS-121 iyisivimbeli se-acetyl-CoA carboxylase 1 (ACC1) esisuselwa ku-quinolone futhi esisebenza ngomlomo esinezakhiwo zezokwelapha ezithembisayo. Ucwaningo olunzulu luye lwenziwa ukuze kuhlolwe izinzuzo ezingaba khona ze-CMS-121 ezindaweni ezahlukene, okuhlanganisa ukuvikela izinzwa, imiphumela yokulwa nokuvuvukala, umsebenzi we-antioxidant, kanye nomthelela wayo ezimpawini ezihambisana nokuguga okunempilo.
