Umkhiqizi we-Mitoquinone Bromide Inombolo ye-CAS: 336184-91-9 Ubumsulwa obungu-25% ubuncane. Izithako zezithako

Incazelo emfushane:

I-Mitoquinone bromide iyi-analog ye-Coenzyme Q10 ekhonjiswe ukuthi inomsebenzi onamandla wokulwa ne-antioxidant. I-Mitoquinone, eyaziwa nangokuthi i-MitoQ, iwuhlobo oluhlukile lwe-Coenzyme Q10 (CoQ10) oluhlasela futhi luqongelele ngqo kuma-mitochondria, izikhungo zamandla zeseli.

Sithumelele i-imeyili

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Amapharamitha Omkhiqizo

Igama lomkhiqizo	I-Mitoquinone Bromide
Elinye igama	i-mitoquinone bromide I-Mito-Q I-MitoQ i-mitoquinone i-mitoquinone cation (10-(4,5-Dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl)triphenylphosphonium bromide I-DMRUQISFVFDWGE-UHFFFAOYSA-M 10-(6'-ubiquinolyl)decyltriphenylphosphonium J-690299 [10-(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl]triphenyl-phosphonium Bromide
Inombolo ye-CAS	336184-91-9
Ifomula yama-molecule	C₃₇H₄₄O₄I-BrP
Isisindo sama-molecule	663.6
Ubumsulwa	25%
Ukubukeka	Impuphu ephuzi noma ephuzi kancane
Ukupakisha	1kg/isikhwama, 25kg/ibhareli
Isicelo	Izinto Zokusetshenziswa Zokudla Ezingeziwe

Isingeniso somkhiqizo

I-Mitoquinone bromide iyi-analog ye-Coenzyme Q10 ekhonjiswe ukuthi inomsebenzi onamandla we-antioxidant. I-Mitoquinone, eyaziwa nangokuthi i-MitoQ, iwuhlobo oluhlukile lwe-Coenzyme Q10 (CoQ10) oluhlose futhi luqoqeke ngqo kwi-mitochondria, izikhungo zamandla zeseli. Ngokungafani nama-antioxidants avamile angaba nobunzima bokungena kulwelwesi lwe-mitochondrial, i-Mitoquinone yenzelwe ukufinyelela ngempumelelo kule organelle ebalulekile lapho iveza khona imiphumela yayo enamandla ye-antioxidant. I-Bromide iyi-ion eshajeke kabi enefomula yamakhemikhali i-Br⁻. Iyingxenye ebalulekile ezinhlobonhlobo zezimpendulo zamakhemikhali, ikakhulukazi ekuphenduleni kwe-SN2 lapho ingasebenza khona njenge-nucleophile noma i-radical eyi-ionizing. I-Mitoquinone bromide ihloselwe kwi-mitochondria ngokunamathiselwa kwe-covalent ku-lipophilic triphenylphosphine cation. Ngenxa yamandla amakhulu e-mitochondrial membrane, i-cation iqoqana izikhathi ezifika ku-1,000 ku-mitochondria kune-non-target antioxidants njenge-Coenzyme Q noma ama-analogue ayo, okuvumela ukuthi i-antioxidant ivimbele i-lipid peroxidation futhi ivikele i-mitochondria ekulimaleni kwe-oxidative. Ngokuvimba ngokukhetha umonakalo we-mitochondrial oxidative, ivimbela ukufa kweseli. I-Mitoquinone bromide ingaba ngumlamuleli owusizo wokusetshenziswa kwe-oxygen ye-mitochondrial.

Isici

(1) Ubumsulwa obuphezulu: I-Mitoquinone bromide ingathola imikhiqizo yobumsulwa obuphezulu ngezinqubo zokukhiqiza zokucwenga. Ubumsulwa obuphezulu busho ukutholakala okungcono kwe-bioavailability kanye nokusabela okuncane okubi.

(2) Ukuphepha: Ukuphepha okuphezulu, ukusabela okungekuhle okumbalwa.

(3) Ukuzinza: I-Mitoquinone bromide izinzile kahle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.

Izicelo

Uma kubhekwa ukuguga, ukwehla komsebenzi we-mitochondrial kanye nokuqongelela komonakalo we-oxidative kuyizinto ezibalulekile enkambisweni yokuguga. Imiphumela eqondiwe ye-antioxidant ye-mitoquinones ibenza babe ngabantu abanamandla bokungenelela okuhloswe ukukhuthaza ukuguga okunempilo kanye nokuphila isikhathi eside. Ngaphezu kwalokho, izakhiwo zayo zokuvikela izinzwa zingase zilibazise ukwehla kokuqonda okuhlobene nokuguga, okusihlinzeka ngendlela engaba khona yokugcina amandla okuqonda ngesikhathi senqubo yokuguga. I-Mitoquinone iphinde yadonsela ukunaka ngenxa yamandla ayo e-antioxidant emkhakheni wokunakekelwa kwesikhumba. Isikhumba sihlala sibhekene nezinto ezibangela ukucindezeleka kwemvelo futhi sisengozini enkulu yokulimala kwe-oxidative. Ngokusebenzisa amandla e-quinones ye-mitochondrial, isikhumba esisha nesikhanyayo singatholakala.