Umkhiqizi wempuphu we-Oleoylethanolamide (OEA) Inombolo ye-CAS: 111-58-0 98%,85% ubumsulwa obuncane bezithako ezengeziwe
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-Oleoyl ethanolamide |
| Elinye igama | i-N-oleoyl ethanolamine; I-N-(2-hydroxyethyl)-,(Z)-9-Octadecenamide |
| Inombolo ye-CAS | 111-58-0 |
| Ifomula yama-molecule | C20H39NO2 |
| Isisindo sama-molecule | 325.53 |
| Ubumsulwa | 98.0% ，85.0% |
| Ukubukeka | Impuphu yekristalu emhlophe enhle |
| Ukupakisha | 1kg/isikhwama, 25kg/isigubhu |
| Isicelo | Ukuqeda ubuhlungu, ukulwa nokuvuvukala |
Isingeniso somkhiqizo
I-Oleoylethanolamide iyinhlanganisela yesibili ye-amide eyakhiwe yi-lipophilic oleic acid kanye ne-hydrophilic ethanolamine. I-Oleoylethanolamide futhi iyi-molecule ye-lipid eyenzeka ngokwemvelo kwezinye izicubu zezilwane nezitshalo. Itholakala kabanzi ezicutshini zezilwane nezitshalo njengempuphu ye-cocoa, ubhontshisi, namantongomane, kodwa okuqukethwe kwayo kuphansi kakhulu. Kuphela uma indawo yangaphandle ishintsha noma ukudla kukhuthazwa, izicubu zeseli zomzimba Kulapho kuphela lapho kuzokhiqizwa khona okuningi kwalokhu okubalulekile.
Emazingeni okushisa egumbi, i-Oleoylethanolamide iyi-solid emhlophe enezinga lokuncibilika elingaba ngu-50°C. Incibilika kalula ezinyibilikisini ezidakayo ezifana ne-methanol ne-ethanol, incibilika kalula ezinyibilikisini ezingezona ezi-polar ezifana ne-n-hexane ne-ether, futhi ayincibiliki emanzini. I-OEA iyi-molecule e-amphiphilic evame ukusetshenziswa njenge-surfactant kanye ne-detergent embonini yamakhemikhali. Kodwa-ke, ucwaningo olwengeziwe luthole ukuthi i-OEA ingasebenza njenge-molecule yokubonisa i-lipid ku-gut-brain axis futhi ibonise uchungechunge lwemisebenzi yezinto eziphilayo emzimbeni, okuhlanganisa: ukulawula isifiso sokudla, ukuthuthukisa i-lipid metabolism, ukuthuthukisa inkumbulo kanye nokuqonda kanye neminye imisebenzi. Phakathi kwazo, imisebenzi ye-Oleoylethanolamide yokulawula isifiso sokudla kanye nokuthuthukisa i-lipid metabolism ithole ukunakwa okukhulu.
I-Oleoylethanolamide ingalawula ukudla kanye ne-homeostasis yamandla ngokusebenzisa i-receptor-α evuselelwa yi-peroxisome proliferator. Ngaphezu kwalokho, i-Oleoylethanolamide ibonisa eminye imisebenzi ehlobene nempilo, okuhlanganisa nokuguqula umsebenzi wokuguqula indlela yokubonisana ye-lysosomal-to-nuclear ehlotshaniswa nokulawulwa kokuphila isikhathi eside kanye nokuvikela izinzwa ezilawula ukuziphatha kokucindezeleka. Ucwaningo luphinde luphakamise ukuthi i-Oleoylethanolamide ingaba nemiphumela yokuvikela izinzwa. Kumamodeli ezilwane, kutholakale ukuthi inciphisa umonakalo ovela ekushayweni yisifo sohlangothi kanye nokulimala kobuchopho okubuhlungu. Umphumela wokulawula we-Oleoylethanolamide ubangelwa ukubopha kwayo ku-PPARα, encipha nge-retinoid X receptor (RXR) futhi iyisebenze njengesici esinamandla sokubhala esihilelekile ku-homeostasis yamandla ahlanganisiwe, i-lipid metabolism, i-autophagy, kanye nokuvuvukala.
Isici
(1) Ubumsulwa obuphezulu: I-OEA ingathola imikhiqizo yobumsulwa obuphezulu ngezinqubo zokukhiqiza zokucwenga. Ubumsulwa obuphezulu busho ukutholakala okungcono kwe-bioavailability kanye nokusabela okuncane okubi.
(2) Ukuphepha: I-OEA ifakazelwe ukuthi iphephile emzimbeni womuntu.
(3) Ukuzinza: I-OEA inozinzo oluhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.
(4) Kulula ukumunca: I-OEA ingamuncwa ngokushesha ngumzimba womuntu futhi isatshalaliswe ezicutshini nasezithweni ezahlukene.
Izicelo
I-Oleoylethanolamide iyi-lipid yemvelo ye-ethanolamide esetshenziswa njengohlelo lokulawula ukudla kanye nesisindo somzimba ezinhlobonhlobo zezilwane ezinomgogodla. Iyi-metabolite ye-oleic acid eyakhiwe emathunjini amancane omuntu. I-Oleylethanolamide (OEA) iyi-molecule elawula i-lipid metabolism kanye ne-energy homeostasis. Inamathela kuma-receptor e-PPAR Alpha futhi isiza ukulawula izici ezine: indlala, amafutha omzimba, i-cholesterol kanye nesisindo. I-PPAR Alpha imele i-peroxide proliferator-activated receptor alpha, kanti i-bioactive lipid amide oleoylethanolamide (OEA) inezakhiwo ezahlukahlukene ze-homeostatic ezihlukile, kufaka phakathi umsebenzi wokulwa nokuvuvukala, ukuguqulwa kwempendulo yomzimba, kanye nemiphumela ye-antioxidant.
