Umkhiqizi wempuphu we-1-(1-Adamantylcarbonyl)proline (ACA) Inombolo ye-CAS: 35084-48-1 Ubumsulwa obungu-98% obuncane bezithako ezengeziwe
Ividiyo Yomkhiqizo
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-proline engu-1-(1-Adamantylcarbonyl) |
| Elinye igama | 1-(1-ADAMANTYLCARBONYL)PYRROLIDINE-2-CARBOXYLIC ACID; 1-(ADAMANTANE-1-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID; 1-(1-Adamantylcarbonyl)proline;L-Proline, 1-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)- |
| Inombolo ye-CAS | 35084-48-1 |
| Ifomula yama-molecule | C16H23NO3 |
| Isisindo sama-molecule | 277.36 |
| Ubumsulwa | 98.0% |
| Ukubukeka | Impuphu emhlophe |
| Ukupakisha | 1kg/isikhwama 10kg/isigubhu 25kg/isigubhu |
| Isicelo | I-Nootropic |
Isingeniso somkhiqizo
I-1-(1-Adamantylcarbonyl) proline iyi-phenylalanine derivative, eyaziwa nangokuthi i-adamantylproline noma i-Ad-Pro. Isetshenziswa kakhulu njenge-catalyst noma i-chiral resolution reagent ekuhlanganisweni kwezinto eziphilayo. Izifundo zibonise ukuthi i-1-(1-Adamantylcarbonyl) proline ingavuselela ukusabela kokungezwa kwe-nucleophilic okungalingani, njengokusabela kwe-aldehydes ne-alkylene azides, ukusabela kwe-aldehydes ne-sulfuryl folate, ukusabela kwe-aldehydes ne-nitro Methane reactions, njll. Phakathi kwalezi zimpendulo, le catalyst inomsebenzi oqine kakhulu wokwengeza kuma-alkylene azides. I-1-(1-Adamantylcarbonyl) proline ingavuselela nokusabela kwe-asymmetric amination. I-1-(1-Adamantylcarbonyl) proline ingasetshenziswa futhi njenge-chiral catalyst ukuze ivuselele i-alcoholization engalingani. Isibonelo, ingaphendula ama-alcohols nama-aldehydes noma ama-ketone ukuze iveze imikhiqizo ehambisanayo ye-aldol noma i-hydroxyketone. I-proline engu-1-(1-Adamantylcarbonyl), njenge-chiral organic compound, inomsebenzi omuhle kakhulu wokuvuselela.
Isici
(1)1-(1-Adamantylcarbonyl) i-proline iyimpuphu emhlophe noma engemhlophe enokuncibilika okuhle. Inokuncibilika okuncane emanzini kodwa ivame ukuncibilika okuhle ezincibilikisini eziphilayo. Iyinhlanganisela eqinile engagcinwa ekamelweni lokushisa isikhathi eside.
(2) I-proline engu-1-(1-Adamantylcarbonyl) iyi-molecule ye-chiral enama-enantiomer amabili. Uhlobo lwayo lwe-chiral luyenza isetshenziswe kabanzi ekwakhiweni kwe-chiral. Ngokuvamile, kufanele kusetshenziswe i-isomer eyodwa ye-chiral ngenxa yokufakwa kwayo okuhle kwe-chiral.
(3) Ukuhlanzeka okuphezulu: I-proline engu-1-(1-Adamantylcarbonyl) ingathola imikhiqizo ehlanzeka kakhulu ngezinqubo zokukhiqiza zokucwenga. Ukuhlanzeka okuphezulu kusho ukutholakala okungcono kwe-bioavailability kanye nokusabela okuncane okubi.
(4) Ukuzinza: I-proline engu-1-(1-Adamantylcarbonyl) izinzile kahle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.
Izicelo
I-1-(1-Adamantylcarbonyl) proline iyinhlanganisela ephilayo equkethe i-nitrogen, impuphu emhlophe noma engekho mhlophe, esetshenziswa njenge-intermediate kanye nezinye izinhlelo zokusebenza kwezokwelapha. Ngaphezu kwalokho, ngenxa yezakhiwo zayo ezihlukile ze-chiral, isetshenziswa kabanzi ekuhlanganisweni kwe-chiral organic, kufaka phakathi ukusabela kwe-nucleophilic asymmetric, ukusabela kwe-amination, ukusabela kwe-alcoholization, njll.
